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In 2013, ProBioGen issued a non-exclusive license to Emergent BioSolutions for ProBioGen’s avian AGE1.CR cell line for the production of vaccines against infectious diseases. ProBioGen also recently licensed the technology to Merus, a cancer therapeutics company. Enhancing ADCC increases the therapeutic effect and reduces side effects. The technology integrates a heterologous enzyme into antibody producer cell lines, interfering with the cells’ intracellular fucose biosynthesis pathway, thereby enhancing Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC). In June 2014, ProBioGen announced that it licensed its GlymaxX Antibody Glyco-Engineering technology to Novartis on a non-exclusive basis. The acquisition occurred after a long history of successful cooperation between the two companies. ProBioGen was acquired by Minapharm Pharmaceuticals in 2010. The manufacturing expansion will allow the company to improve the technique and develop other novel biotechnological processes to produce cell lines. Thomas Rose, molecular biologist, has pioneered a new way to increase cellular production by stimulating the cellular secretion apparatus. The company manufactures pre-clinical and GMP-grade material, specializing in therapeutic glyco-proteins and viral vaccines.
ProBioGen is authorized for GMP-compliant manufacturing by the European Medicines Agency (EMA) and the Food and Drug Administration (FDA). Wolf said, "With an investment of around 20 million euros, we will strengthen our market position.” The company also intends to build two bioreactors and increase staff from 75 to 150. The funds are to be used in GMP (Good Manufacturing Practice) manufacturing of biopharmaceuticals. Wieland Wolf made the announcement to ceremony guests in Berlin, Germany. ProBioGen, a contract development and manufacturing organization (CDMO) announced in a press release that it intends to invest €20 million in its biopharmaceutical manufacturing enterprise.
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